jQuery .closest() gets the first element that matches the selector, beginning at the current element and progressing up through the DOM tree;
js:
$('.target').closest('.parent').css('background-color', '#ffa');
html:
<div class="well"> <div class="well parent">.parent <div class="well"> <div class="well"> <span class="target">.target</span> </div> </div> </div> </div>